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Department of Medicine, Faculty of Medicine & Health Sciences, Stell. Univ.

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Immunology and Infectious Diseases

(adapted to incorporate the required learning material from both the Part 1 and the Part 2 Syllabus documents as published by the college)

IMMUNE SYSTEM

CORE SCIENCES

Anatomy

·         Microanatomy of the lymphnode and thymus

·         Systemic lymphatic drainage

Physiology

·         Host defence mechanisms – innate and adaptive

·         Cells and the immune system

·         Neutrophil recruitment and functions

·         T-cell recognition and activation

·         Antigen processing and activation

·         Acute phase proteins, heat shock proteins and tumor necrosis factor

·         Complement system

·         Roles of cytokines, interferons and chemokines

·         Arachidonic acid metabolism

·         Mechanism of inflammation including autoimmune responses

·         Synthesis, structure and function of immunoglobulins

·         Hypersensitivity immuneresponses – types I – IV

·         HLA system and function

·         Changes with aging

DIAGNOSTIC MODALITIES

Principles, indications for and interpretation of the following:

·         Skin prick tests

·         Immunoglobulin assays

·         Complement assays

·         White cell differential count

·         Antibody mediated diagnostic tests eg. ELISA

·         Biomarkers of inflammation

APPLEID BASIC SCIENCES

The etiology, pathogenesis and pathophysiology of the following:

·         Hypersensitivity reactions

INFECTIOUS DISEASES

CORE SCIENCES

Definitions of terms

·         Epidemic

·         Pandemic

·         Endemic

Microbiology/Virology

·         Classification of microbial pathogens

·         Mechanisms of reproduction of microbial pathogens

Physiology

·         Systemic response to inflammation and infection

·         Immunology of septic shock

Therapeutics

·         Classification of antimicrobials

·         PK/PD of major antibacterial agents

·         Mechanisms of action of different classes antimicrobials

·         Mechanisms of antimicrobial resistance

Infection prevention and control

·         Measures to limit spread of infection

·         Measures to limit spread of antimicrobial resistance

·         Limiting an outbreak of disease

DIAGNOSTIC MODALITIES

Microscopy, culture and sensitivity

·         Specimen collection and interpretation

Serology

·         Principles and interpretation

APPLEID BASIC SCIENCES

The etiology, pathogenesis and pathophysiology of the following:

Amoebiasis

Cholera

Cysticercosis

Fever of unknown origin

HIV/AIDS

Hydatid disease

Immunization and vaccines

Malaria

Nosocomial infections

Opportunistic infections

Other common infections in adults

Rabies

Schistosomiasis

Sepsis

STI’s

Tetanus

Tick bite fever

Tuberculosis

Typhoid

Viral hemorrhagic fever

Worm infestations

ID covered elsewhere in syllabus:

RESP

Defence mechanisms of the lung, Pneumonia, Lung abscess,  Empyema, Pulmonary & pleural TB, HIV/AIDS pulmonary manifestations

NEURO

Meningitis, Meningo-encephalitis, HIV/AIDS neurological manifestations

RHEUMA

Septic arthritis, Reactive arthritis, TB spine/hip, HIV/AIDS rheumatological manifestations

NEPHRO

UTI, Antimicrobial drug induced renal disease, HIV/AIDS renal manifestations

CARDIO

Infective endocarditis, HIV/AIDS cardiac manifestations

ENDO

Infection in diabetes mellitus; HIV/AIDS and metabolic disease

GIT & LIVER

Interpretation of viral hepatitis studies, viral hepatitis, liver abscess, diarrhea, dysentery, TB of the GIT, Antimicrobial drug induced liver disease, HIV/AIDS GIT/liver manifestations

PHARMA

Principles of pharmacokinetics and pharmacodynamics; Classification, spectrum and mechanisms of action of antimicrobial agents, Mechanisms of antimicrobial resistance, indications for and interpretation of therapeutic drug levels

HAEMA

HIV/AIDS haematological manifestations (Anaemia, neutropaenia, thrombocytopaenia, thrombophillia, bicytopaenia, pancytopaenia, isolated red cell aplasia)

FCP 1 content not adequately covered by Ganong:

Harrison’s Infetious Diseases (available on Registrars website)

·         Section I – Chapters 1 and 2  - Introduction to ID

·         Section II – Chapter 7 – Fever (only page 84 and 85)

·         Section IV – Chapter 33 – Bacterial infections

·         Section V – Part 1 – Viral infections

·         Mechanisms of reproduction of microbial agents (focus on common and important organisms)

o   HIV, Malaria, Rabies, Echinococcus, Cysticercosis, Hepatitis B etc.


The Era of Molecular and Other Non-Culture-Based Methods in Diagnosis of Sepsis

Inflammatory Markers in the 21st Century (PDF)

Pharmacokonetics/Pharmacodynamics for Critical Care Clinicians (PDF)

Procalcitonin: an Emerging Biomarker of Bacterial Sepsis (PDF)

To download all of the above PDFs as a ZIP file, right click on this link and select Save As.

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